11 de Noviembre de 2014
Artículo con referato

LDSO: A program to simulate pedigrees and molecular information under various evolutionary forces

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Autores

Dana Leticia ROLDAN

,
F. YTOUMEL
,
S. TEYSSÈDRE
,
M. ERBE
,
H. SIMIANER
,
D. BOICHARD
,
H. GILBERT
,
T. DRUET
,
A. LEGARRA

Simulations are important to evaluate new statistical methods in the genomic era. However, the
properties of a new method can only be accurately evaluated if the simulated situations are close
enough to real situations, but also if the diversity of simulated situations is realistic enough. It is thus
important to account as much as possible for the various evolutionary forces existing in livestock
populations  (e.g.  mutation,  random  drift,  changes  in  population  sizes  and  selection)  and  for  the
genetic effects (additive, dominant etc.). We present here a simulation program (LDSO) accounting
for them and providing a diversity of outputs related to the linkage disequilibrium structure and the
identity between haplotypes in the population, facilitating further data analyses. Furthermore, LDSO
enables the simulation of genomic data in known pedigree, which sticks as precisely as possible to
recent population history and the structure of the long-range.

Referencias

Áreas geográficas alcanzadas
    • Argentina
    • Buenos Aires
    • Castelar